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The Bejerano Lab at Stanford University developed the Genomic Regions Enrichment of Annotations Tool (GREAT) and hosts the GREAT web server at http://bejerano.stanford.edu/great.

Many coding genes are well annotated with their biological functions. Non-coding regions typically lack such annotation. GREAT assigns biological meaning to a set of non-coding genomic regions by analyzing the annotations of the nearby genes. Thus, it is particularly useful in studying cis functions of sets of non-coding genomic regions. Cis-regulatory regions can be identified via both experimental methods (e.g. chromatin immunoprecipitation followed by massively parallel sequencing) and by computational methods (e.g. sequence conservation in a given clade).


Read about our newly-available GREAT Version 2.0 release which adds genomic region/gene distribution plots and improves the term details page.




  • Genome Assemblies - Which genome assemblies does GREAT support, and can I use other assemblies or species?
  • File Formats - What should my test regions and background regions files contain?
  • File Size - What data set sizes can GREAT handle?
  • Data Integrity - What checks does GREAT perform to ensure my data is valid?
  • Background Sets - When should I use an explicit background set in evaluating enrichments?


  • Statistics - How does GREAT calculate enrichments, and how should I interpret my results?
  • Output - What output does GREAT provide?
  • Genes - Which set of genes does GREAT use, and how does GREAT determine a single transcription start site for a gene?
  • Visualizations - How can GREAT help you visualize your data for publication or better analysis?
  • Ontologies - What is an ontology, and what data do the ontologies in GREAT provide?


  • Web Browsers - Which web browsers does GREAT support, and how can I make my browser work best with GREAT?
  • Programming Interface - How can I submit data sets to GREAT automatically through a script or directly from my web site?


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