The MSigDB Perturbation1 ontology contains gene sets that represent gene expression signatures of genetic and chemical perturbations. A number of these gene sets come in pairs: an xxx_UP (xxx_DN) gene set representing genes induced (repressed) by the perturbation.
The human ontology contains 911 gene sets, 11,189 genes, and 67,052 associations.
The mouse ontology contains 248 gene sets, 7,419 genes, and 23,073 associations.
All data for this ontology was downloaded on March 11, 2009 (MSigDB version 2.5).
|1||Subramanian, A., et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles, Proc Natl Acad Sci U S A. 2005 Oct 25; 102(43):15545-50.|