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The HUGO Gene Nomenclature Committee (HGNC) Gene Families

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Bruford, E.A., The HGNC Database in 2008: a resource for the human genome, Nucleic Acids Res. 2008 Jan; 36(Database issue):D445-8.

[1] ontology contains data on gene families based on sequence similarity, data from the literature and other databases, and manual curation.

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GREAT v1.2 HGNC Gene Families statistics are available here.

References

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Bruford, E.A., The HGNC Database in 2008: a resource for the human genome, Nucleic Acids Res. 2008 Jan; 36(Database issue):D445-8.