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In addition to the above association rules, GREAT utilizes a set of literature curated regulatory domains. Where experimental evidence demonstrates that a gene is directly regulated by an element that falls outside of its putative regulatory domain (as defined by the default Basal plus extension rule), GREAT includes a curated regulatory domain that extends the regulatory domain for the gene to include its known regulatory element. The curated regulatory domains override the automatic rules. To ignore the curated regulatory domains, uncheck the option to "Include curated regulatory domains" in the Association rule settings area of the input screen.

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