- A tool to calculate computationally-defined gene regulatory domains.
- A tool to calculate the genomic region-based binomial enrichment p-value for ontology terms given the regulatory domains of genes annotated with the term and the input regions associated with the term.
To download and install compile the tools, perform the following steps:
- Download the source code tarball
- Unpack the tarball using the command '
tar xzvf greatTools.tar.gz'
- Follow installation the instructions given in the
The logic for associating regions with genes and calculating enrichments is also completely fully described in our Nature Biotechnology paper.
All of the data included in the GREAT ontologies is publicly available, and we provide links or references for every ontology. We do not currently offer our processed ontology these data for download, but as all data is available from the original sources. Additionally, the GREAT web tool offers numerous "Export" functions to save all ontology data as it pertains to your sets.
GREAT Gene Sets
Please refer to Genes for instructions on how to download the gene set used by GREAT.