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The binomial p-value equals the probability of having k? or more of the n test genomic regions in the regulatory domain of a gene with annotation ? given that the probability of that occurring for a single genomic region is p?.

Binomial P-value = Image Modified

What is the hypergeometric test formally?

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The hypergeometric p-value equals the probability of choosing k? or more genes with annotation ? when randomly drawing n genes from the genome.

Hypergeometric P-value = Image Modified

Example

Explicit Background Set

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The hypergeometric statistic equals the probability of choosing k? or more genomic regions with annotation ? when randomly drawing n genomic regions from the background set.

Hypergeometric P-value = Image Modified

How should I interpret the statistics provided by GREAT? Which test is more important - the binomial or the hypergeometric?

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