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March 26, 2010

  • Changed the layout of input page: now uses an expanding section for association rule settings, instead of a separate tab.
  • Added a checkbox to include curated regulatory domains.
  • Changed the default set of output columns.
  • Added the ability to revise association rule settings.
  • Added a global filter for observed gene hits.
  • Improved and simplified the exported HTML.
  • More efficient memory use by loading genes and regions only on demand.


January 05, 2010

  • Fixed a bug which caused the term filter to be ignored after changing the minimum binomial fold enrichment value.


December 10, 2009

  • Added filtering based on minimum binomial fold enrichment
  • Fixed bug which prevented display of term details pages for term names containing an apostrophe in them.
  • Corrected some column labels.
  • Fixed some typos.


November 20, 2009

  • Revised order of some of the input page's help text.
  • Code changes to parameterize some otherwise constant values.


October 30, 2009

  • Server-side changes only.


August 7, 2009

  • Updated release.



See our versioning policy here.


February 15, 2015

  • Ontology terms are now mapped to Ensembl Release 73 Genes.
  • The mouse mm10 assembly is now supported.
  • New ontologies of MSigDB Immunologic Signatures and MSigDB Oncogenic Signatures are now added. Ontologies of transcription factor targets and miRNA targets  have been dropped in GREAT 3.0 but are still in version 2.0.
  • The hg18 human assembly is not supported in GREAT version 3.0 but is still supported in GREAT version 2.0.


April 3, 2012

  • Mouse and human ontology data has been updated with new data so reproducing results prior to 2.0 need to be done using 1.8
  • Extended programming interface to allow batch jobs to receive tsv output
  • Added the export "All data as .tsv" option to "Global Export".
  • The export for individual ontologies was also extended to output gene and regions hit and the FDR values.
  • Added data visualization features to GREAT
    • Export tables as barplots
    • View enriched terms in hierarchy
  • New modern CSS skin
  • Zebrafish ontology data remains identical to GREAT 1.8 and thus can be reproduced using the 2.0 interface


May 31, 2011

  • Added genomic region/gene association graphs to main results page.
  • Enhanced the term details page to:
    • Include term-specific graphs,
    • Link specifically between genomic regions and genes, and
    • Open UCSC genome browser shots at a gene's regulatory domain.
  • Added informative error messages when an input BED file has errors.
  • All previously-existing ontology data remain identical to GREAT 1.5, 1.6, and 1.7, so reproducing GREAT 1.5, 1.6, or 1.7 runs happens automatically in 1.8.


March 29, 2011

  • Added support for two phenotype ontologies (Human Phenotype and Osborne Annotated Disease Ontology) in the human and mouse assemblies.
  • All previously-existing ontology data remain identical to GREAT 1.5 and 1.6, so reproducing GREAT 1.5 and 1.6 runs happens automatically in 1.7.


Jan 27, 2011

  • Added support for the zebrafish Zv9 (UCSC danRer7, Jul/2010) assembly.
  • All human- and mouse-related data remain identical to GREAT 1.5, so reproducing GREAT 1.5 runs happens automatically in 1.6.


Nov 19, 2010


May 2, 2010


Apr 27, 2009

  • First internal release.