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Our implementation of the core calculation logic used by GREAT is available for download. This package is written in C and includes two tools:

  1. A tool to calculate computationally-defined gene regulatory domains
  2. A tool to calculate the genomic region-based binomial enrichment p-value for ontology terms given the regulatory domains of genes annotated with the term and the input regions associated with the term.

The logic for associating regions with genes and calculating enrichments is also completely described in our Nature Biotechnology paper.

Ontology Data

All of the data included in the GREAT ontologies is publicly available, and we provide links or references for every ontology. We do not currently offer our processed ontology data for download, but all data is available from the original sources. Additionally, the GREAT web tool offers numerous "Export" functions to save all ontology data as it pertains to your sets.