Many coding genes are well annotated with their biological functions. Non-coding regions typically lack such annotation. GREAT assigns biological meaning to a set of non-coding genomic regions by analyzing the annotations of the nearby genes. Thus, it is particularly useful in studying cis functions of sets of non-coding genomic regions. Cis-regulatory regions can be identified via both experimental methods (e.g. chromatin immunoprecipitation followed by massively parallel sequencing) and by computational methods (e.g. sequence conservation in a given clade).
Read about our newly-available GREAT Version 1.6 release which adds zebrafish to the species GREAT supports.
- Overview - When is GREAT useful, and for which uses should I prefer it to other annotation tools?
- Video - Watch a video presentation on GREAT
- Citation - How do I cite GREAT?
- Publications & Reprints
- Version History
- About Us
- Contact Us - Mailing lists and contact information
- Genome Assemblies - Which genome assemblies does GREAT support, and can I use other assemblies or species?
- File Formats - What should my test regions and background regions files contain?
- File Size - What data set sizes can GREAT handle?
- Data Integrity - What checks does GREAT perform to ensure my data is valid?
- Background Sets - When should I use an explicit background set in evaluating enrichments?
- Statistics - How does GREAT calculate enrichments, and how should I interpret my results?
- Output - What output does GREAT provide?
- Genes - Which set of genes does GREAT use, and how does GREAT determine a single transcription start site for a gene?
- Ontologies - What is an ontology, and what data do the ontologies in GREAT provide?
- Web Browsers - Which web browsers does GREAT support, and how can I make my browser work best with GREAT?
- Programming Interface - How can I send data sets directly to GREAT?