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Many coding genes are well annotated with their biological functions. Non-coding regions typically lack such annotation. GREAT, the Genomic Regions Enrichment of Annotations Tool, assigns biological meaning to a set of non-coding genomic regions by analyzing the annotations of the nearby genes. Thus, it is useful in studying cis functions of non-coding genomic regions.

The Bejerano Lab developed GREAT and hosts the GREAT web server.


  • Overview - When is GREAT useful, and for which uses should I prefer it to other annotation tools?
  • Statistics - How does GREAT calculate enrichments, and how should I interpret results?
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