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Many coding genes are well annotated with their biological functions. Non-coding regions typically lack such annotation. GREAT, the Genomic Regions Enrichment of Annotations Tool, assigns biological meaning to a set of non-coding genomic regions by analyzing the annotations of the nearby genes. Thus, it is useful in studying cis functions of non-coding genomic regions.

The Bejerano Lab developed GREAT and hosts the GREAT web server.


  • Overview - When is GREAT useful, and for which uses should I prefer it to other annotation tools?
  • Statistics - How does GREAT calculate enrichments, and how should I interpret my results?
  • Background Sets - Why should I use a background set in evaluating enrichments?
  • File Formats - What should my test regions and background regions files contain?
  • Citation - How do I cite GREAT?
  • Genes - Which set of genes does GREAT use?
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