OMIMOnlineMendelianInheritanceinManAll DatabasesPubMedNucleotideProteinGenomeStructurePMCTaxonomyOMIM SearchPubMedProteinNucleotideCoreNucleotideGSSESTStructureGenomeBooksCancerChromosomesConservedDomainsdbGaP3DDomainsGeneGenomeProjectGENSATGEOProfilesGEODataSetsHomoloGeneJournalsMeSHNCBIWebSiteNLMCatalogOMIAOMIMPMCPopSetProbeProteinClustersPubChemBioAssayPubChemCompoundPubChemSubstanceSNPTaxonomyToolKitUniGeneUniSTSLimitsPreview/IndexHistoryClipboardDetailsDisplayTitlesDetailedClinicalSynopsisAllelicVariantsASN1XMLLinkOutRelatedEntriesBookLinksGeneLinksGenomeLinksGEOProfileLinksHomoloGeneLinksNucleotideLinksOMIALinksPubChemBioAssayLinksPMCLinksProteinLinksPubMed(calculated)LinksPubMed(cited)LinksSNPLinksGeneGenotypeLinksStructureLinksUniGeneLinksUniSTSLinksShow5102050100200500SendtoTextFilePrinterClipboardAll1OMIMdbSNP0OMIMUniSTS0*603710LinksADISINTEGRINANDMETALLOPROTEINASEDOMAIN23ADAM23AlternativetitlessymbolsMETALLOPROTEINASELIKEDISINTEGRINLIKEANDCYSTEINERICHPROTEIN3MDC3Genemaplocus2q33TEXTDESCRIPTIONThecellulardisintegrinsalsoknownasADAM(adisintegrinandmetalloproteinase)andMDC(metalloproteinaselikedisintegrinlikeandcysteinerich)proteinsareaclassofpotentialcelladhesionmoleculesCLONINGBysearchinganESTdatabaseforsequencesrelatedtoMDC(155120)Saganeetal(1998)identifiedapartialMDC3cDNATheyscreenedahumanbraincDNAlibraryandused3primeRACEtocloneadditionalcDNAscorrespondingtotheentireMDC3codingregionThepredicted832aminoacidproteincontainsthetypicalcellulardisintegrindomains(seeMDC2603709)HoweverthezincbindingmotifwhichiscriticalforproteinaseactivityisdisruptedinMDC3aswellastheotherMDCproteinsMDC3sharesapproximately52%sequencesimilaritywithMDCandMDC2NorthernblotanalysisrevealedthatMDC3wasexpressedpredominantlyinbrainasseveraltranscriptsranginginsizefrom35to7kbMAPPINGByradiationhybridanalysisPoindexteretal(1999)mappedtheADAM23genetochromosome2q33REFERENCES1PoindexterKNelsonNDuBoseRFBlackRACerrettiDPTheidentificationofsevenmetalloproteinasedisintegrin(ADAM)genesfromgenomiclibrariesGene23761701999PubMedID105242372SaganeKOhyaYHasegawaYTanakaIMetalloproteinaselikedisintegrinlikecysteinerichproteinsMDC2andMDC3novelhumancellulardisintegrinshighlyexpressedinthebrainBiochemJ33493981998PubMedID9693107CONTRIBUTORSCarolABocchiniupdated6/27/2002CREATIONDATERebekahSRasooly4/8/1999EDITHISTORYterry6/27/2002mgross4/13/1999Copyright©19662007JohnsHopkinsUniversityDisplayTitlesDetailedClinicalSynopsisAllelicVariantsASN1XMLLinkOutRelatedEntriesBookLinksGeneLinksGenomeLinksGEOProfileLinksHomoloGeneLinksNucleotideLinksOMIALinksPubChemBioAssayLinksPMCLinksProteinLinksPubMed(calculated)LinksPubMed(cited)LinksSNPLinksGeneGenotypeLinksStructureLinksUniGeneLinksUniSTSLinksShow5102050100200500SendtoTextFilePrinterClipboardDisclaimerWritetotheHelpDeskPrivacyPolicyNCBINLMNIH