OMIMOnlineMendelianInheritanceinManAll DatabasesPubMedNucleotideProteinGenomeStructurePMCTaxonomyOMIM SearchPubMedProteinNucleotideCoreNucleotideGSSESTStructureGenomeBooksCancerChromosomesConservedDomainsdbGaP3DDomainsGeneGenomeProjectGENSATGEOProfilesGEODataSetsHomoloGeneJournalsMeSHNCBIWebSiteNLMCatalogOMIAOMIMPMCPopSetProbeProteinClustersPubChemBioAssayPubChemCompoundPubChemSubstanceSNPTaxonomyToolKitUniGeneUniSTSLimitsPreview/IndexHistoryClipboardDetailsDisplayTitlesDetailedClinicalSynopsisAllelicVariantsASN1XMLLinkOutRelatedEntriesBookLinksGeneLinksGenomeLinksGEOProfileLinksHomoloGeneLinksNucleotideLinksOMIALinksPubChemBioAssayLinksPMCLinksProteinLinksPubMed(calculated)LinksPubMed(cited)LinksSNPLinksGeneGenotypeLinksStructureLinksUniGeneLinksUniSTSLinksShow5102050100200500SendtoTextFilePrinterClipboardAll1OMIMdbSNP0OMIMUniSTS0*607549LinksANKYRINREPEATDOMAINCONTAININGPROTEIN21ANKRD21AlternativetitlessymbolsPROSTATEOVARYTESTISANDPLACENTAEXPRESSEDGENEPOTEPROSTATEOVARYTESTISANDPLACENTAEXPRESSEDGENEONCHROMOSOME21POTE21Genemaplocus21q112TEXTCLONINGByscreeninganESTdatabaseforprostatespecificgenesBeraetal(2002)identifiedPOTETheyclonedthefulllengthPOTEcDNAfromaprostatecDNAlibraryThededuced584aminoacidproteinhasacalculatedmolecularmassof664kDPOTEcontains5to7ankyrinrepeatsaputativetransmembraneregionwhichisinbetweenandpartlyoverlapswithankyrinrepeats5and6andanalphahelicalCterminusRTPCRandmultitissuedotblotanalysisdetectedrobustexpressioninprostateandtestisandweakexpressioninplacentaandovaryNorthernblotanalysisdetecteda20kbtranscriptinprostateandtestisPOTEwasalsoexpressedinaleukemiacelllineandinanandrogenresponsiveprostatecancercelllineitwasnotdetectedinanandrogenunresponsiveprostatecancercelllineInsituhybridizationdetectedaPOTEtranscriptexpressedinthebasalandterminalepithelialcellsofnormalprostateepitheliumandinprostatecancercellsGENESTRUCTUREBeraetal(2002)determinedthatthePOTEgenecontains11exonsandspansabout32kbMAPPINGBygenomicsequenceanalysisandFISHBeraetal(2002)mappedthePOTEgenetochromosome21q112FISHdetectedparalogsofPOTEonchromosomes2(608914)8(608915)1314(608916)15(608912)18and22(608913)REFERENCES1BeraTKZimonjicDBPopescuNCSathyanarayanaBKKumarVLeeBPastanIPOTEahighlyhomologousgenefamilylocatedonnumerouschromosomesandexpressedinprostateovarytestisplacentaandprostatecancerProcNatAcadSci9916975169802002NoteErratumProcNatAcadSci1001462only2003PubMedID12475935CREATIONDATEPatriciaAHartz2/6/2003EDITHISTORYmgross9/22/2005mgross9/13/2004alopez5/13/2004mgross2/25/2003mgross2/6/2003Copyright©19662007JohnsHopkinsUniversityDisplayTitlesDetailedClinicalSynopsisAllelicVariantsASN1XMLLinkOutRelatedEntriesBookLinksGeneLinksGenomeLinksGEOProfileLinksHomoloGeneLinksNucleotideLinksOMIALinksPubChemBioAssayLinksPMCLinksProteinLinksPubMed(calculated)LinksPubMed(cited)LinksSNPLinksGeneGenotypeLinksStructureLinksUniGeneLinksUniSTSLinksShow5102050100200500SendtoTextFilePrinterClipboardDisclaimerWritetotheHelpDeskPrivacyPolicyNCBINLMNIH