OMIMOnlineMendelianInheritanceinManAll DatabasesPubMedNucleotideProteinGenomeStructurePMCTaxonomyOMIM SearchPubMedProteinNucleotideCoreNucleotideGSSESTStructureGenomeBooksCancerChromosomesConservedDomainsdbGaP3DDomainsGeneGenomeProjectGENSATGEOProfilesGEODataSetsHomoloGeneJournalsMeSHNCBIWebSiteNLMCatalogOMIAOMIMPMCPopSetProbeProteinClustersPubChemBioAssayPubChemCompoundPubChemSubstanceSNPTaxonomyToolKitUniGeneUniSTSLimitsPreview/IndexHistoryClipboardDetailsDisplayTitlesDetailedClinicalSynopsisAllelicVariantsASN1XMLLinkOutRelatedEntriesBookLinksGeneLinksGenomeLinksGEOProfileLinksHomoloGeneLinksNucleotideLinksOMIALinksPubChemBioAssayLinksPMCLinksProteinLinksPubMed(calculated)LinksPubMed(cited)LinksSNPLinksGeneGenotypeLinksStructureLinksUniGeneLinksUniSTSLinksShow5102050100200500SendtoTextFilePrinterClipboardAll1OMIMdbSNP0OMIMUniSTS0*608008LinksANNEXINA10ANXA10Genemaplocus4q33TEXTDESCRIPTIONANXA10isamemberoftheannexinfamilyofcalciumdependentphospholipidbindingproteinsAnnexinshaveuniqueNterminaldomainsandhomologousCterminaldomainscontainingthecalciumdependentphospholipidbindingsitesCLONINGByESTdatabasesearchingwithannexincDNAsasqueriesMorganetal(1999)identifiedanovelmemberoftheannexinfamilywhichtheydesignatedANXA10inbothhumanandmouseThededucedhuman324aminoacidproteinsharesapproximately89%sequenceidentitywiththemouseproteinANXA10wasfoundtobetheleastrepresentedannexinintheESTdatabaseanditsexpressionwasdetectedonlyinnondifferentiatedtissuesOtherdistinctivefeaturesofANXA10includedacodondeletioninconservedrepeat3andanunusualablationofthetypeIIcalciumbindingsitesintetradcorerepeats13and4GENEFUNCTIONMorganetal(1999)suggestedthattheablationordepletionofprincipalcalciumbindingsitesinannexinsA9(603319)andA10respectivelymaydisposethemtofunctionindistincttissueenvironmentswherecalciumsensitivityisnotamajorfunctionaldeterminantMAPPINGByFISHMorganetal(1999)mappedtheANXA10genetochromosome4q33Byinterspecificbackcrossanalysistheymappedthemouseorthologtomidchromosome8REFERENCES1MorganROJenkinsNAGilbertDJCopelandNGBalsaraBRTestaJRFernandezMPNovelhumanandmouseannexinA10arelinkedtothegenomeduplicationsduringearlychordateevolutionGenomics6040491999PubMedID10458909CREATIONDATECarolABocchini8/4/2003EDITHISTORYcarol8/4/2003carol8/4/2003Copyright©19662007JohnsHopkinsUniversityDisplayTitlesDetailedClinicalSynopsisAllelicVariantsASN1XMLLinkOutRelatedEntriesBookLinksGeneLinksGenomeLinksGEOProfileLinksHomoloGeneLinksNucleotideLinksOMIALinksPubChemBioAssayLinksPMCLinksProteinLinksPubMed(calculated)LinksPubMed(cited)LinksSNPLinksGeneGenotypeLinksStructureLinksUniGeneLinksUniSTSLinksShow5102050100200500SendtoTextFilePrinterClipboardDisclaimerWritetotheHelpDeskPrivacyPolicyNCBINLMNIH