OMIMOnlineMendelianInheritanceinManAll DatabasesPubMedNucleotideProteinGenomeStructurePMCTaxonomyOMIM SearchPubMedProteinNucleotideCoreNucleotideGSSESTStructureGenomeBooksCancerChromosomesConservedDomainsdbGaP3DDomainsGeneGenomeProjectGENSATGEOProfilesGEODataSetsHomoloGeneJournalsMeSHNCBIWebSiteNLMCatalogOMIAOMIMPMCPopSetProbeProteinClustersPubChemBioAssayPubChemCompoundPubChemSubstanceSNPTaxonomyToolKitUniGeneUniSTSLimitsPreview/IndexHistoryClipboardDetailsDisplayTitlesDetailedClinicalSynopsisAllelicVariantsASN1XMLLinkOutRelatedEntriesBookLinksGeneLinksGenomeLinksGEOProfileLinksHomoloGeneLinksNucleotideLinksOMIALinksPubChemBioAssayLinksPMCLinksProteinLinksPubMed(calculated)LinksPubMed(cited)LinksSNPLinksGeneGenotypeLinksStructureLinksUniGeneLinksUniSTSLinksShow5102050100200500SendtoTextFilePrinterClipboardAll1OMIMdbSNP0OMIMUniSTS0*102593LinksACYLOXYACYLHYDROLASEAOAHGenemaplocus7p14p12TEXTAcyloxyacylhydrolase(AOAH)isa2subunitlipasepresentinphagocyticcellsThisenzymespecificallyhydrolyzesthesecondaryacylchainsofthelipopolysaccharidefoundinthewallsofgramnegativebacteriaAlthoughthephysiologicfunctionofAOAHhasnotbeenclearlydefineditsactiononlipopolysaccharide(orendotoxin)suggeststhatitmodulatesthehost'sinflammatoryresponsetogramnegativebacteriaThishypothesisissupportedbystudiesshowingthatthedeacylationoflipopolysaccharidebyAOAHinvitrogreatlyreducesitstoxicityandactivityHagenetal(1991)clonedandcharacterizedcDNAforhumanAOAHandshowedthatits2subunitsaretranslatedfromasinglemRNAmoleculeabout22kblongByfluorescenceinsituhybridizationWhitmoreetal(1994)mappedtheAOAHgeneto7p14p12REFERENCES1HagenFSGrantFJKuijperJLSlaughterCAMoomawCROrthKO'HaraPJMunfordRSExpressionandcharacterizationofrecombinanthumanacyloxyacylhydrolasealeukocyteenzymethatdeacylatesbacteriallipopolysaccharidesBiochemistry30841584231991PubMedID18838282WhitmoreTEMathewesSLO'HaraPJDurnamDMChromosomallocalizationoftheacyloxyacylhydrolase(AOAH)geneto7p14p12usingfluorescenceinsituhybridizationGenomics214574581994PubMedID8088847CREATIONDATEVictorAMcKusick6/17/1994EDITHISTORYjason6/17/1994Copyright©19662007JohnsHopkinsUniversityDisplayTitlesDetailedClinicalSynopsisAllelicVariantsASN1XMLLinkOutRelatedEntriesBookLinksGeneLinksGenomeLinksGEOProfileLinksHomoloGeneLinksNucleotideLinksOMIALinksPubChemBioAssayLinksPMCLinksProteinLinksPubMed(calculated)LinksPubMed(cited)LinksSNPLinksGeneGenotypeLinksStructureLinksUniGeneLinksUniSTSLinksShow5102050100200500SendtoTextFilePrinterClipboardDisclaimerWritetotheHelpDeskPrivacyPolicyNCBINLMNIH