OMIMOnlineMendelianInheritanceinManAll DatabasesPubMedNucleotideProteinGenomeStructurePMCTaxonomyOMIM SearchPubMedProteinNucleotideCoreNucleotideGSSESTStructureGenomeBooksCancerChromosomesConservedDomainsdbGaP3DDomainsGeneGenomeProjectGENSATGEOProfilesGEODataSetsHomoloGeneJournalsMeSHNCBIWebSiteNLMCatalogOMIAOMIMPMCPopSetProbeProteinClustersPubChemBioAssayPubChemCompoundPubChemSubstanceSNPTaxonomyToolKitUniGeneUniSTSLimitsPreview/IndexHistoryClipboardDetailsDisplayTitlesDetailedClinicalSynopsisAllelicVariantsASN1XMLLinkOutRelatedEntriesBookLinksGeneLinksGenomeLinksGEOProfileLinksHomoloGeneLinksNucleotideLinksOMIALinksPubChemBioAssayLinksPMCLinksProteinLinksPubMed(calculated)LinksPubMed(cited)LinksSNPLinksGeneGenotypeLinksStructureLinksUniGeneLinksUniSTSLinksShow5102050100200500SendtoTextFilePrinterClipboardAll1OMIMdbSNP0OMIMUniSTS1*605333LinksANDROGENINDUCEDPROSTATEPROLIFERATIVESHUTOFFASSOCIATEDPROTEINAlternativetitlessymbolsAS3Genemaplocus13q123TEXTIntheprostateofadultmammalsmostepithelialcellsareinastateofproliferativequiescenceAndrogensregulatethiseffectbyinducingcellcyclearrestintheG0/G1phaseGecketal(2000)identifiedpotentialmediatorsofthisandrogeninducedproliferativeshutoffbymeansofsubtractivecDNAlibrariesTheexpressionpatternofoneofthesesequencesdesignatedAS3stronglycorrelatedwiththeexpressionoftheandrogeninducedproliferativeshutoffbothtemporallyanddosewiseTheAS3geneisupregulatedduringandrogeninducedproliferativeshutoffandinducescellproliferationarrestwhenexpressedinaretrovirustransducedmodelThededuced1391aminoacidAS3proteinhasputativetransactivatingfeaturesproteinproteininteractionmotifs(coiledcoilandleucinezipper)andDNAbindingdomainssuggestingthatAS3isatranscriptionfactorAS3alsohasaproteinkinasemotifsuggestingthatitmayactbyphosphorylatingatargetproteinGecketal(1999)demonstratedthatthetranscriptoftheAS3genehas34exonsspanningapproximately200kbofgenomicDNAByhomologysearchinginGenBanktheydemonstratedthattheAS3genelieson13q12q13downstreamofthebreastcancersusceptibilitygeneBRCA2(600185)andcentromerictotheretinoblastoma(RB1180200)locusGecketal(2001)presenteddataonthelocationoftheAS3geneinrelationtoBRCA2andpointedoutthattheD13S171markerwhichhadbeenwidelyusedasanintragenicmarkerofBRCA2isactuallylocatedinthecenterofthe200kbAS3geneThemicrosatelliteinstabilityoftheS171markerlinkstheAS3genetoavarietyofcancersREFERENCES1GeckPMaffiniMVSzeleiJSonnenscheinCSotoAMAndrogeninducedproliferativequiescenceinprostatecancercellstheroleofAS3asitsmediatorProcNatAcadSci9710185101902000PubMedID109636802GeckPSonnenscheinCSotoAMTheD13S171markermisannotatedtoBRCA2linkstheAS3genetovariouscancers(Letter)AmJHumGenet694614632001PubMedID114523633GeckPSzeleiJJimenezJSonnenscheinCSotoAMEarlygeneexpressionduringandrogeninducedinhibitionofproliferationofprostatecancercellsanewsuppressorcandidateonchromosome13intheBRCA2Rb1locusJSteroidBiochemMolecBiol6841501999PubMedID10215036CONTRIBUTORSVictorAMcKusickupdated8/30/2001VictorAMcKusickupdated2/26/2001CREATIONDATEVictorAMcKusick10/12/2000EDITHISTORYcwells9/21/2001cwells9/17/2001terry8/30/2001mcapotos3/8/2001mcapotos3/2/2001terry2/26/2001carol10/13/2000Copyright©19662007JohnsHopkinsUniversityDisplayTitlesDetailedClinicalSynopsisAllelicVariantsASN1XMLLinkOutRelatedEntriesBookLinksGeneLinksGenomeLinksGEOProfileLinksHomoloGeneLinksNucleotideLinksOMIALinksPubChemBioAssayLinksPMCLinksProteinLinksPubMed(calculated)LinksPubMed(cited)LinksSNPLinksGeneGenotypeLinksStructureLinksUniGeneLinksUniSTSLinksShow5102050100200500SendtoTextFilePrinterClipboardDisclaimerWritetotheHelpDeskPrivacyPolicyNCBINLMNIH