OMIMResultMyNCBI[SignIn][Register]Entrez20All DatabasesPubMedNucleotideProteinGenomeStructurePMCTaxonomyOMIM SearchPubMedProteinNucleotideCoreNucleotideGSSESTStructureGenomeBooksCancerChromosomesConservedDomainsdbGaP3DDomainsGeneGenomeProjectGENSATGEOProfilesGEODataSetsHomoloGeneJournalsMeSHNCBIWebSiteNLMCatalogOMIAOMIMPMCPopSetProbeProteinClustersPubChemBioAssayPubChemCompoundPubChemSubstanceSNP SearchPubMedProteinNucleotideCoreNucleotideGSSESTStructureGenomeBooksCancerChromosomesConservedDomainsdbGaP3DDomainsGeneGenomeProjectGENSATGEOProfilesGEODataSetsHomoloGeneJournalsMeSHNCBIWebSiteNLMCatalogOMIAOMIMPMCPopSetProbeProteinClustersPubChemBioAssayPubChemCompoundPubChemSubstanceSNPTaxonomyToolKitUniGeneUniSTSforGoClearLimitsPreview/IndexHistoryClipboardDetails DisplayTitlesDetailedClinicalSynopsisAllelicVariantsASN1XMLLinkOutRelatedEntriesBookLinksGeneLinksGenomeLinksGEOProfileLinksHomoloGeneLinksCoreNucleotideLinksESTLinksGSSLinksNucleotideLinksOMIALinksPubChemBioAssayLinksPMCLinksProteinLinksPubMed(calculated)LinksPubMed(cited)LinksSNPLinksGeneGenotypeLinksStructureLinksUniGeneLinksUniSTSLinksShow5102050100200500SendtoTextFilePrinterClipboard*601177LinksADPRIBOSYLATIONFACTOR4ARF4Genemaplocus3p141TEXTCLONINGMonacoetal(1990)useddegeneratePCRwithgenomicDNAtoidentifyamemberofthehumanADPribosylationfactor(ARF)genefamilyThegenedesignatedARF4encodesapredicted180aminoacidproteinthatisapproximately80%identicaltotheotherhumanARFs(seeforexample103180)and73%identicaltoyeastARFByDNAsequenceanalysistheauthorsstatedthatARF4isthemostdivergentmemberofthehumanARFsAprocessedpseudogenethatis94%identicalatthenucleotidelevelwasalsoidentifiedNorthernblotanalysisdetecteda18kbmRNAinIMR32neuroblastomacellsMAPPINGKim(1998)mappedtheARF4geneto3p141byPCRanalysisofsomaticcellhybridDNAandradiationhybridanalysisREFERENCES1KimHSHumanADPribosylationfactor4(ARF4)genemapposition3p141ChromosomeRes6663only1998PubMedID100998842MonacoLMurtaghJJNewmanKBTsaiSCMossJVaughanMSelectiveamplificationofanmRNAandrelatedpseudogeneforahumanADPribosylationfactoraguaninenucleotidedependentproteinactivatorofcholeratoxinProcNatAcadSci87220622101990PubMedID2107548CONTRIBUTORSJoannaSAmbergerupdated1/22/2004CREATIONDATEAlanFScott4/4/1996EDITHISTORYcarol1/23/2004joanna1/22/2004dkim6/26/1998mark4/4/1996terry4/4/1996mark4/4/1996Copyright©19662007JohnsHopkinsUniversityDisclaimerWritetotheHelpDeskPrivacyPolicyNCBINLMNIHÂ