OMIMOnlineMendelianInheritanceinManAll DatabasesPubMedNucleotideProteinGenomeStructurePMCTaxonomyOMIM SearchPubMedProteinNucleotideCoreNucleotideGSSESTStructureGenomeBooksCancerChromosomesConservedDomainsdbGaP3DDomainsGeneGenomeProjectGENSATGEOProfilesGEODataSetsHomoloGeneJournalsMeSHNCBIWebSiteNLMCatalogOMIAOMIMPMCPopSetProbeProteinClustersPubChemBioAssayPubChemCompoundPubChemSubstanceSNPTaxonomyToolKitUniGeneUniSTSLimitsPreview/IndexHistoryClipboardDetailsDisplayTitlesDetailedClinicalSynopsisAllelicVariantsASN1XMLLinkOutRelatedEntriesBookLinksGeneLinksGenomeLinksGEOProfileLinksHomoloGeneLinksNucleotideLinksOMIALinksPubChemBioAssayLinksPMCLinksProteinLinksPubMed(calculated)LinksPubMed(cited)LinksSNPLinksGeneGenotypeLinksStructureLinksUniGeneLinksUniSTSLinksShow5102050100200500SendtoTextFilePrinterClipboardAll1OMIMdbSNP0OMIMUniSTS0*610589LinksRHOGTPaseACTIVATINGPROTEIN11AARHGAP11AAlternativetitlessymbolsKIAA0013Genemaplocus15q132TEXTCLONINGBysequencingclonesobtainedfromasizefractionatedimmaturemyeloidleukemiacelllinecDNAlibraryNomuraetal(1994)clonedARHGAP11AwhichtheydesignatedKIAA0013ThecDNAcontainsarepetitiveelementatits3primeendandthededuced1023aminoacidproteinhasarhoGAPdomainandaputativetyrosinephosphorylationsiteNorthernblotanalysisdetectedhighestexpressioninthymusintermediateexpressioninplacentakidneytestisandcolonweakexpressioninheartbrainlungliverskeletalmusclepancreasspleenovarysmallintestineandperipheralbloodleukocytesandnoneinprostateMAPPINGByPCRofapanelofhumanrodenthybridcelllinesNomuraetal(1994)mappedtheARHGAP11Agenetochromosome15SEEALSONomuraetal(1994)REFERENCES1NomuraNMiyajimaNSazukaTTanakaAKawarabayasiYSatoSNagaseTSekiNIshikawaKTabataSPredictionofthecodingsequencesofunidentifiedhumangenesIThecodingsequencesof40newgenes(KIAA0001KIAA0040)deducedbyanalysisofrandomlysampledcDNAclonesfromhumanimmaturemyeloidcelllineKG1(Supplement)DNARes1(Suppl)47561994PubMedID75840282NomuraNMiyajimaNSazukaTTanakaAKawarabayasiYSatoSNagaseTSekiNIshikawaKTabataSPredictionofthecodingsequencesofunidentifiedhumangenesIThecodingsequencesof40newgenes(KIAA0001KIAA0040)deducedbyanalysisofrandomlysamplescDNAclonesfromhumanimmaturemyeloidcelllineKG1DNARes127351994PubMedID7584026CREATIONDATEPatriciaAHartz11/21/2006EDITHISTORYwwang11/21/2006Copyright©19662007JohnsHopkinsUniversityDisplayTitlesDetailedClinicalSynopsisAllelicVariantsASN1XMLLinkOutRelatedEntriesBookLinksGeneLinksGenomeLinksGEOProfileLinksHomoloGeneLinksNucleotideLinksOMIALinksPubChemBioAssayLinksPMCLinksProteinLinksPubMed(calculated)LinksPubMed(cited)LinksSNPLinksGeneGenotypeLinksStructureLinksUniGeneLinksUniSTSLinksShow5102050100200500SendtoTextFilePrinterClipboardDisclaimerWritetotheHelpDeskPrivacyPolicyNCBINLMNIH