OMIMOnlineMendelianInheritanceinManAll DatabasesPubMedNucleotideProteinGenomeStructurePMCTaxonomyOMIM SearchPubMedProteinNucleotideCoreNucleotideGSSESTStructureGenomeBooksCancerChromosomesConservedDomainsdbGaP3DDomainsGeneGenomeProjectGENSATGEOProfilesGEODataSetsHomoloGeneJournalsMeSHNCBIWebSiteNLMCatalogOMIAOMIMPMCPopSetProbeProteinClustersPubChemBioAssayPubChemCompoundPubChemSubstanceSNPTaxonomyToolKitUniGeneUniSTSLimitsPreview/IndexHistoryClipboardDetailsDisplayTitlesDetailedClinicalSynopsisAllelicVariantsASN1XMLLinkOutRelatedEntriesBookLinksGeneLinksGenomeLinksGEOProfileLinksHomoloGeneLinksNucleotideLinksOMIALinksPubChemBioAssayLinksPMCLinksProteinLinksPubMed(calculated)LinksPubMed(cited)LinksSNPLinksGeneGenotypeLinksStructureLinksUniGeneLinksUniSTSLinksShow5102050100200500SendtoTextFilePrinterClipboardAll1OMIMdbSNP0OMIMUniSTS0*603425LinksADPRIBOSYLATIONFACTORLIKE1ARL1TEXTADPribosylationfactors(ARFseg600464)initiallydescribedasactivatorsofcholeratoxin(CT)ADPribosyltransferaseactivityregulateintracellularvesicularmembranetraffickingandstimulateaphospholipaseD(PLDeg602382)isoformUsingaPCRbasedcloningstrategyZhangetal(1995)isolatedhumancDNAsencodingARL1adeduced181aminoacidARFlikeproteinwith57%identitytoARF1(103180)AlthoughARLproteinsareverysimilarinsequencetoARFstheywereinitiallythoughtnottoactivateCTorPLDHoweverHongetal(1998)showedthatundercertainconditionsARL1canactivatePLDandenhanceCTcatalyzedADPribosyltransferaseactivityByNorthernblotanalysistheydetected3217and12kbARL1mRNAsinallhumantissuestestedexceptbrainwhichhadonlythe32kbspeciesWesternblotanalysisdemonstratedhighestlevelsofARL1proteininkidneyliverheartandlungREFERENCES1HongJXLeeFJSPattonWALinCYMossJVaughanMPhospholipidandGTPdependentactivationofcholeratoxinandphospholipaseDbyhumanADPribosylationfactorlikeprotein1(HARL1)JBiolChem27315872158761998PubMedID96241892ZhangGFPattonWALeeFJSLiyanageMHanJSRheeSGMossJVaughanMDifferentARFdomainsarerequiredfortheactivationofcholeratoxinandphospholipaseDJBiolChem27021241995PubMedID7814376CREATIONDATESherylAJankowski1/13/1999EDITHISTORYpsherman1/15/1999psherman1/14/1999Copyright©19662007JohnsHopkinsUniversityDisplayTitlesDetailedClinicalSynopsisAllelicVariantsASN1XMLLinkOutRelatedEntriesBookLinksGeneLinksGenomeLinksGEOProfileLinksHomoloGeneLinksNucleotideLinksOMIALinksPubChemBioAssayLinksPMCLinksProteinLinksPubMed(calculated)LinksPubMed(cited)LinksSNPLinksGeneGenotypeLinksStructureLinksUniGeneLinksUniSTSLinksShow5102050100200500SendtoTextFilePrinterClipboardDisclaimerWritetotheHelpDeskPrivacyPolicyNCBINLMNIH