OMIMOnlineMendelianInheritanceinManAll DatabasesPubMedNucleotideProteinGenomeStructurePMCTaxonomyOMIM SearchPubMedProteinNucleotideCoreNucleotideGSSESTStructureGenomeBooksCancerChromosomesConservedDomainsdbGaP3DDomainsGeneGenomeProjectGENSATGEOProfilesGEODataSetsHomoloGeneJournalsMeSHNCBIWebSiteNLMCatalogOMIAOMIMPMCPopSetProbeProteinClustersPubChemBioAssayPubChemCompoundPubChemSubstanceSNPTaxonomyToolKitUniGeneUniSTSLimitsPreview/IndexHistoryClipboardDetailsDisplayTitlesDetailedClinicalSynopsisAllelicVariantsASN1XMLLinkOutRelatedEntriesBookLinksGeneLinksGenomeLinksGEOProfileLinksHomoloGeneLinksNucleotideLinksOMIALinksPubChemBioAssayLinksPMCLinksProteinLinksPubMed(calculated)LinksPubMed(cited)LinksSNPLinksGeneGenotypeLinksStructureLinksUniGeneLinksUniSTSLinksShow5102050100200500SendtoTextFilePrinterClipboardAll1OMIMdbSNP0OMIMUniSTS0*608909LinksADPRIBOSYLATIONFACTORLIKE8ARL8TEXTDESCRIPTIONARL8belongstoafamilyofproteinsthatarestructurallysimilartoADPribosylationfactors(ARFssee103180)ARLsandARFsarepartoftheRASsuperfamilyofregulatoryGTPasesCLONINGBysequencingclonesobtainedfromacartilagecDNAlibrarySebaldetal(2003)identifiedARL8Thededuced179aminoacidproteincontainssequencesconservedinotherARLsincludingthosethatbindMg(2+)andothersinvolvedinGTPbindingandhydrolysisARL8ismostrelatedtoARL5withwhichitshares80%aminoacididentityARL8shares100%identitywithmouseArl8and71%identitywiththeDrosophilahomologNorthernblotanalysisdetecteda67kbmouseArl8transcriptinbrainheartlungcartilageandkidneybutnotinspleenAnalternate87kbtranscriptwasdetectedinpostnatalmousebrainbutnotinadultmousebrainNorthernblotanalysisdetectedweakexpressionofhumanARL8inbrainbutnotinspleenGENESTRUCTURESebaldetal(2003)determinedthattheARL8genecontains6exonsandspans179kbMAPPINGBygenomicsequenceanalysisSebaldetal(2003)mappedtheARL8genetochromosome10p13TheymappedthemouseArl8genetochromosome2AREFERENCES1SebaldEKruegerRKingLMCohnDHKrakowDIsolationofanewmemberoftheADPribosylationlikefactorgenefamilyARL8fromacartilagecDNAlibraryGene3111471512003PubMedID12853149CREATIONDATEPatriciaAHartz9/10/2004EDITHISTORYmgross9/10/2004Copyright©19662007JohnsHopkinsUniversityDisplayTitlesDetailedClinicalSynopsisAllelicVariantsASN1XMLLinkOutRelatedEntriesBookLinksGeneLinksGenomeLinksGEOProfileLinksHomoloGeneLinksNucleotideLinksOMIALinksPubChemBioAssayLinksPMCLinksProteinLinksPubMed(calculated)LinksPubMed(cited)LinksSNPLinksGeneGenotypeLinksStructureLinksUniGeneLinksUniSTSLinksShow5102050100200500SendtoTextFilePrinterClipboardDisclaimerWritetotheHelpDeskPrivacyPolicyNCBINLMNIH