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FATTY ACID CoA LIGASE, LONG-CHAIN 2; FACL2

Alternative titles; symbols

LONG-CHAIN ACYL-CoA SYNTHETASE 2; LACS2
PALMITOYL-CoA LIGASE 2
FATTY ACID CoA LIGASE, LONG-CHAIN 1; FACL1
LONG-CHAIN ACYL-CoA SYNTHETASE; LACS
ACYL-CoA SYNTHETASE 1; ACS1
PALMITOYL-CoA LIGASE 1

Gene map locus 4q34-q35

TEXT

DESCRIPTION

Activation of long-chain fatty acids by the long-chain acyl-coenzyme A synthetase (LACS) is the first reaction in their metabolism. Thus, this enzyme, which is also known as palmitoyl-CoA ligase (EC 6.2.1.3), plays a key role in both the synthesis of cellular lipids and the degradation of fatty acids.

CLONING

Suzuki et al. (1990) isolated and sequenced a cDNA for rat LACS. Minoshima et al. (1991) isolated a human cDNA for LACS from a human liver cDNA library using the rat cDNA as a probe.

MAPPING

Using flow-sorted human chromosomes, Minoshima et al. (1991) demonstrated that the FACL2 gene is located on human chromosome 4. However, using in situ hybridization, Stanczak et al. (1992) mapped the gene, which they called FACL1, to 3q13. Cantu et al. (1995) confirmed that the FACL2 gene maps to 4q34-q35 by fluorescence in situ hybridization.

REFERENCES

1. Cantu, E. S.; Sprinkle, T. J.; Ghosh, B.; Singh, I. :

The human palmitoyl-CoA ligase (FACL2) gene maps to the chromosome 4q34-q35 region by fluorescence in situ hybridization (FISH) and somatic cell hybrid panels. Genomics 28: 600-602, 1995.
PubMed ID : 7490105

2. Minoshima, S.; Fukuyama, R.; Yamamoto, T.; Shimizu, N. :

Mapping of human long-chain acyl-CoA synthetase to chromosome 4. (Abstract) Cytogenet. Cell Genet. 58: 1888 only, 1991.

3. Stanczak, H.; Stanczak, J. J.; Singh, I. :

Chromosomal localization of the human gene for palmitoyl-CoA ligase (FACL1). Cytogenet. Cell Genet. 59: 17-19, 1992.
PubMed ID : 1531127

4. Suzuki, H.; Kawarabayasi, Y.; Kondo, J.; Abe, T.; Nishikawa, K.; Kimura, S.; Hashimoto, T.; Yamamoto, T. :

Structure and regulation of rat long-chain acyl-CoA synthetase. J. Biol. Chem. 265: 8681-8685, 1990.
PubMed ID : 2341402

CREATION DATE

Victor A. McKusick : 8/6/1991

EDIT HISTORY

mgross : 1/6/2004
mgross : 2/22/2001
terry : 4/25/2000
alopez : 10/1/1998
dkim : 7/24/1998
alopez : 2/20/1998
alopez : 2/20/1998
carol : 1/20/1995
terry : 5/11/1994
carol : 5/18/1992
supermim : 3/16/1992
carol : 2/22/1992
carol : 2/14/1992

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