Alternative titles; symbols
ACYL-CoA SYNTHETASE 3; ACS3
Gene map locus
2q34-q35
TEXT
See FACL2 (152425). An initial reaction in fatty acid metabolism in eukaryotic cells is activation of fatty acids catalyzed by acyl-CoA synthetase (ACS; EC 6.2.1.3). Fujino et al. (1996) identified a member of the ACS family by PCR of rat brain cDNAs using primers based on the conserved region of the ACS protein, and designated it ACS3. The 720-amino acid, approximately 80-kd rat protein preferentially utilizes myristate, laurate, arachidonate, and eicosapentaenoate, and is expressed primarily in brain. 
Minekura et al. (1997) used rat ACS3 cDNA as a probe to isolate a human ACS3 clone from a placental cDNA library. The predicted 720-amino acid human protein is 92% identical to that of rat ACS3. Minekura et al. (1997) used PCR of somatic cell hybrids and fluorescence in situ hybridization to map the ACS3 gene to 2q34-q35.
REFERENCES
- 1. Fujino, T.; Kang, M.-J.; Suzuki, H.; Iijima, H.; Yamamoto, T. :
- Molecular characterization and expression of rat acyl-CoA synthetase 3. J. Biol. Chem. 271: 16748-16752, 1996.
PubMed ID : 8663269
- 2. Minekura, H.; Fujino, T.; Kang, M.-J.; Fujita, T.; Endo, Y.; Yamamoto, T. T. :
- Human acyl-coenzyme A synthetase 3 cDNA and localization of its gene (ACS3) to chromosome band 2q34-q35. Genomics 42: 180-181, 1997.
PubMed ID : 9177793
CREATION DATE
Rebekah S. Rasooly : 2/20/1998
EDIT HISTORY
mgross : 1/6/2004
mgross : 2/22/2001
terry : 4/25/2000
alopez : 10/1/1998
alopez : 2/20/1998
Copyright © 1966-2007 Johns Hopkins University