Alternative titles; symbols
LAK
KIAA1527
Gene map locus
Chr.4TEXT
DESCRIPTION
Unlike most eukaryotic kinases, alpha kinases, such as LAK, recognize phosphorylation sites in which the surrounding peptides have an alpha-helical conformation.
CLONING
By EST database searching for homologs of the alpha kinase EEF2K (606968), Ryazanov et al. (1999) identified LAK, which they termed 'chromosome 4 kinase.'
By screening for cDNAs with the potential to encode large proteins expressed in brain, Nagase et al. (2000) identified a partial cDNA encoding LAK, which they called KIAA1527. Using RT-PCR analysis, they detected moderate expression of LAK in all tissues tested except liver, where expression was high. 
MAPPING
By genomic sequence analysis, Ryazanov et al. (1999) and Nagase et al. (2000) mapped the LAK gene to chromosome 4.
REFERENCES
- 1. Nagase, T.; Kikuno, R.; Ishikawa, K.; Hirosawa, M.; Ohara, O. :
- Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 7: 143-150, 2000.
PubMed ID : 10819331
- 2. Ryazanov, A. G.; Pavur, K. S.; Dorovkov, M. V. :
- Alpha-kinases: a new class of protein kinases with a novel catalytic domain. Curr. Biol. 9: R43-R45, 1999.
PubMed ID : 10021370
CREATION DATE
Paul J. Converse : 11/14/2002
EDIT HISTORY
mgross : 11/14/2002
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