OMIM Result

*608008 Links

ANNEXIN A10; ANXA10

Gene map locus 4q33

TEXT

DESCRIPTION

ANXA10 is a member of the annexin family of calcium-dependent phospholipid-binding proteins. Annexins have unique N-terminal domains and homologous C-terminal domains containing the calcium-dependent phospholipid-binding sites.

CLONING

By EST database searching with annexin cDNAs as queries, Morgan et al. (1999) identified a novel member of the annexin family, which they designated ANXA10, in both human and mouse. The deduced human 324-amino acid protein shares approximately 89% sequence identity with the mouse protein. ANXA10 was found to be the least represented annexin in the EST database, and its expression was detected only in nondifferentiated tissues. Other distinctive features of ANXA10 included a codon deletion in conserved repeat 3, and an unusual ablation of the type II calcium-binding sites in tetrad core repeats 1, 3, and 4.

GENE FUNCTION

Morgan et al. (1999) suggested that the ablation or depletion of principal calcium-binding sites in annexins A9 (603319) and A10, respectively, may dispose them to function in distinct tissue environments where calcium sensitivity is not a major functional determinant.

MAPPING

By FISH, Morgan et al. (1999) mapped the ANXA10 gene to chromosome 4q33. By interspecific backcross analysis, they mapped the mouse ortholog to mid-chromosome 8.

REFERENCES

1. Morgan, R. O.; Jenkins, N. A.; Gilbert, D. J.; Copeland, N. G.; Balsara, B. R.; Testa, J. R.; Fernandez, M. P. :: Novel human and mouse annexin A10 are linked to the genome duplications during early chordate evolution. Genomics 60: 40-49, 1999.
PubMed ID : 10458909

CREATION DATE

Carol A. Bocchini : 8/4/2003

EDIT HISTORY

carol : 8/4/2003
carol : 8/4/2003