Bejerano Lab

The Bejerano Lab studies genome function in human and related species. We are deeply interested in the following broad questions:

  • Mapping genome sequence (variation) to phenotype (differences)
  • Extracting specific genetic insights from deep sequencing measurements
We take a particular interest in gene cis regulation. Only 2-3% of the 3 billion bases in the human genome encode the genome's 25,000 protein coding genes, and a similar number of non-coding genes. Roughly 1,000,000 promoters, enhancers, silencers and insulators regulate coding and non-coding gene expression in every cell in our body. We study this fascinating "control layer" of the human genome to reveal how these loci:
  • Encode the causality of cell differentiation
  • Affect disease susceptibility and treatment
  • Provide substrate for phenotype evolution
  • Allow targeting of specific cell populations
We use our joint affiliation to apply a combination of computational and experimental approaches. We collect large scale experimental data; write computational analysis tools; run them massively to discover the most exciting testable hypotheses; which we proceed to experimentally validate. We work in small teams, in house or with close collaborators, of experimentalists and computational tool users who interact directly with our computational tool builders. See our projects for more details.

      [last modified 2013/10/14 01:21] Bejerano LabDepartment of Developmental Biology and Department of Computer ScienceStanford University